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  Automated Cell Imagers
  
  Lionheart FX Automated Microscope
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  Multi-Plate Live Cell Imaging System
  
  BioSpa Live Cell Analysis System
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  Multi-Mode Microplate Readers
  
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  Multi-Plate Absorbance Reader
  
  LogPhase 600 Microbiology Reader
  Absorbance Microplate Readers
  
  Epoch 2 Microplate Spectrophotometer
  Epoch Microplate Spectrophotometer
  ELx808 Absorbance Reader
  800 TS Absorbance Reader
  Peripherals
  
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  BioSpa 8 Automated Incubator
  BioStack Microplate Stacker
  BenchCel Microplate Handler
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Applications
- Cell Culture QC
  
  Automated imaging tools can provide valuable information for improving routine cell culturing techniques and increasing the effectiveness and reproducibility of downstream cell-based assays. Conventional methods for evaluating cell culturing techniques and assay design consist of manual inspection of a small subset of the cell population at random locations and time points.
- Cell Health and Viability
  
  Cell health and viability measurements provide essential insight into a broad range of biological processes and treatment responses. Diverse assay formats and reagents have been developed that measure specific aspects of cell viability corresponding to particular cellular response pathways and mechanisms of injury.
- Cell Metabolism
  
  Cellular metabolism comprises a number of biochemical reactions that occur in concert within the cells of living organisms. These orchestrated reactions, better described as metabolic pathways allow organisms to function and respond to environmental changes. Agilent cell metabolism assays detect discrete changes in cell bioenergetics in real time, providing a window into the critical functions that provide ATP, the energy that cells need for activation, signaling, proliferation, and biosynthesis.
- Cell Migration and Invasion
  
  Cell migration and invasion are live cell kinetic assays useful in oncology research. The principle difference between migration and invasion is that migration refers to normal cell movement; whereas invasion describes cells actively invading surrounding tissue. It can do this under the influence of a chemoattractant gradient and secretion of proteases. There are numerous methods for performing these assays including scratch assays performed on a monolayer of cells adhered to plasticware (microplates or culture inserts) or using 3D cell culture models.
- Developmental Biology
  A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. An approach following this viewpoint is the use of whole organism models involving living invertebrates and vertebrates such as nematodes and zebrafish conducive to drug screening methods.
- Histology and Slide Scanning
  Histology is typically performed on fixed tissue samples using upright microscopes equipped with oculars. Cytation™ and Lionheart™ FX provide automated digital imaging of these samples using color brightfield microscopy. Low to high magnifications from 1.25x to 60x (100x with Lionheart FX) can be combined with Cytation Gen5™ image processing features such as image stitching to increase field of view.
- Immunology
  The immune system relies on diverse mechanisms working in concert to defend the host from infection and to identify and remove aberrant or damaged cells. Dysregulation of the immune system can lead to a variety of disease conditions, including autoimmune disorders, allergies, and cancer. Additionally, the immune system is a critical consideration for vaccine development and cell, tissue and organ transplants.
- Immuno-Oncology
  While harnessing the patient’s immune system to fight cancer is not a new concept, there have been significant strides in the past decade to more effectively direct and activate components of the immune system and counter the measures certain tumors adopt to shield itself from immune attack. These include immunotherapeutic drugs based on directing immune cells to tumors based on specific antigens they present, PD-1 checkpoint inhibition and the ex vivo manipulation of the patient’s own immune cells to better drive an immune response to cancer.
- Microbiology
  Since the advent of a lens system that enabled the visualization of bacteria and protists in 1671, the microscope remains a ubiquitous tool for the scientific study of live and fixed microorganisms. Investigating the structure, function, and typing of the highly diverse array of microorganisms spans heterogeneous applications including, but not limited to, the elucidation, diagnosis, and treatment of human and plant disease, food and water safety testing, vaccine development, investigation and production of industrial lipases, protein transfection to mammalian cells, environmental health and impact appraisal, horticultural and agricultural soil assessment, and exploration of alternative fuel sources.
- Molecular Biology and Biochemical
  Biochemical assays run the gamut from routine ELISAs to micro-volume nucleic acid and protein quantification. Endpoint and kinetic, single- and multi-wavelength assays are essential experimental tools. BioTek’s multi-mode readers have the flexibility to accommodate a very broad range of applications with superior performance.
- Rapid Cell Signaling
  G-protein coupled, seven-transmembrane (7-TM) receptors (GPCRs) represent large, diverse gene families found in fungi, plants and animals. The GPCR family of receptors is involved primarily with internalizing extracellular environmental signals via interaction with intracellular G-proteins. GPCR ligands and modulators range from peptide and non-peptide molecules to chemokines, nucleosides, growth factors and light.
- Stem Cell Research
  Research into the reprogramming of somatic cells into pluripotent stem cells received the Nobel Prize in 2012. The long term importance of this research resides in the use of stem cells for regenerative therapies; for the short term, however these cells represent a potential unlimited source of highly physiologically relevant cells, akin to human primary cells, that can be used as drug discovery reagents.
- Virology
  Research into the diverse aspects of virology are made possible by a broad range of applications and assay formats, from relatively simple methods for viral detection to those designed to elucidate complex immune responses and pathological processes. BioTek instruments provide versatile platforms for conducting viral research, with optimized imaging- and plate reader-based solutions, as well as liquid handling and automation tools for increased assay throughput and reproducibility.
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  BioTek’s Visual Abstracts are brief, animated presentations that describe the workflow of a single specific application. Imaging & microscopy-focused Visual Abstracts explain the Augmented Microscopy workflow for a wide range of assays, with key capture>process>analyze>publish concepts presented. Other Visual Abstracts describe the utility of BioTek’s liquid handling and multi-mode instruments in a variety of applications. Check back often for our latest additions to the Visual Abstract library!
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  Synergy H1’s Continuously Variable Bandwidth Monochromators Optimize Assay Performance
  July 2, 2020 - BioTek Instruments announces the availability of variable bandwidth monochromators on their modular and versatile Synergy™ H1 Hybrid Multi-Mode Reader. This allows researchers to achieve even greater levels of assay sensitivity and specificity compared to fixed bandwidth systems. Read more
  
  LogPhase 600 Microbiology Reader Measures Microbial Growth Curves in Multiple Microplates
  June 9, 2020 - BioTek unveils a unique class of microplate readers with the new LogPhase 600 Microbiology Reader. The LogPhase 600 is the only four-plate microplate reader purpose-built to perform microbial growth curve analysis. Multiple plate measurements increase throughput and reduce the need for multiple costly single-plate absorbance readers that take up valuable bench space. At the same time, highly consistent environmental conditions support high quality absorbance results without growth curve artifacts, even in bacterial and yeast assays with extended incubation periods. Read more
  
  Agilent’s BenchCel Microplate Handler Now Available through BioTek for Full Workflow Automation
  May 28, 2020 - BioTek announces that Agilent’s BenchCel Microplate Handler is now added to its portfolio of walkaway automated solutions. The modular BenchCel Microplate Handler is a high-speed robot with an open, flexible and scalable format to bring efficiency to diverse applications such as ELISA, endpoint add-and-read assays and cell fix-stain-image processes. Read more
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Home Products Imaging & Microscopy Cytation 7 Cell Imaging Multi-Mode Reader

Cytation 7 Cell Imaging Multi-Mode Reader

Related Products

Software

Gen5 Microplate Reader and Imager Software controls Cytation 7 for automated image capture, processing, analysis and development of publication-ready images and data. This imaging and microscopy automation represents BioTek’s Augmented Microscopy™ - the simplified, automated process to accomplish multiple microscopy steps in a single platform. Gen5 is available in several editions to meet the image analysis requirements across a range of applications.

Gen5 Image+ offers complete imaging control for Cytation 7, and provides image processing and analysis including z-projection, image stitching, hitpicking and digital phase contrast.

Gen5 Image Prime controls Cytation 7, including more expansive image processing and analysis: Z-projection, image stitching, hitpicking and digital phase contrast, plus advanced features including secondary mask, dynamic thresholding and subpopulation analysis.

Gen5 Secure editions add features to help ensure compliance to 21 CFR Part 11 requirements.

Gen5 add-on modules provide increased functionality for specific applications or analyses, such as Spot Counting.

Object area analysis in Gen5 software.

Quantitative Assay Apps Quant Assay App

BioTek has made it easier than ever to run common applications with only a few clicks from Read to Results! The Quantitative Assay Apps use the power of Gen5 behind a simple, step-by-step setup customization of pre-defined protocols for a streamlined process. Automated data export and report tools complete the workflow requirements.

Peripherals

Part # Description

Application Starter Kits

Part # Description

1750012 Scratch Assay Starter Kit
for Wound Healing and Cell Migration Assays

Sample Files

Imaging

System Files - Imaging Cubes

TRITC, PN 1225125 (25-Sep-20)

Accessories

Download Literature Get more info Request Quote

Gas Controller for CO₂ control

Part Number: 1210007

For use with: Cytation 7

Gas Controller for CO<sub>2</sub> control

Increasingly, life science assays are run on live cells. Some of these assays require control over CO₂ and O₂ concentrations to modulate the environment for pH buffering or to create a hypoxic condition. These assays are traditionally run in flasks in a low-throughput manner, but there is a burgeoning interest in automation of live cell-based assays in microplates for higher throughput and efficiency, therefore there is a need for cell-friendly microplate instrumentation.

The Gas Controller module for Synergy™ H1 allows full control over CO₂ concentrations to regulate the environment for microplate based live cell assays. The Gas Controller and other important cell-friendly features of the Synergy H1, like variable shaking parameters, 4-Zone™ temperature control and a robust mechanical system make them ideal microplate readers for cell-based assays.


Synergy H1 with Gas Controller

Features

Individual or simultaneous control of CO₂ and O₂ levels
CO₂ and O₂ Control Resolution ± 0.1 %
Compact Design
Infrared CO₂ Sensor
Zirconium Oxide O₂ Sensor Simple
Intuitive control panel
Easy to read gas level indicators and alarm LEDs
Alarm buzzer on/off

Models

1210008 Gas Controller for CO₂ and O₂ control. For use with Synergy H1 Hybrid Microplate Reader.

1210007 Gas Controller for CO₂ control only. For use with Synergy H1 Hybrid Microplate Reader.

1210011 Calibration Kit for CO₂ Controller.

01503 Calibrated CO₂ Gas Tank

Specifications

General
Range	CO₂ Control: 0-20% O₂ Control: 1-19%
Control Resolution	CO₂ Control: + 0.1% O₂ Control: + 0.1%
Stability	CO₂ Control: + 0.2% AT 5% CO₂ O₂ Control: + 0.2% AT 1% O₂
Sensor Type	CO₂ Control: Infrared, long lifetime O₂ Control: Zirconium Oxide, long lifetime (no yearly replacement)
Regulatory
Regulatory	All BioTek microplate instrumentation is CE and ETL marked. RoHS Compliant.