General Virology Applications

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- Cell Culture QC
  
  Automated imaging tools can provide valuable information for improving routine cell culturing techniques and increasing the effectiveness and reproducibility of downstream cell-based assays. Conventional methods for evaluating cell culturing techniques and assay design consist of manual inspection of a small subset of the cell population at random locations and time points.
- Cell Health and Viability
  
  Cell health and viability measurements provide essential insight into a broad range of biological processes and treatment responses. Diverse assay formats and reagents have been developed that measure specific aspects of cell viability corresponding to particular cellular response pathways and mechanisms of injury.
- Cell Metabolism
  
  Cellular metabolism comprises a number of biochemical reactions that occur in concert within the cells of living organisms. These orchestrated reactions, better described as metabolic pathways allow organisms to function and respond to environmental changes. Agilent cell metabolism assays detect discrete changes in cell bioenergetics in real time, providing a window into the critical functions that provide ATP, the energy that cells need for activation, signaling, proliferation, and biosynthesis.
- Cell Migration and Invasion
  
  Cell migration and invasion are live cell kinetic assays useful in oncology research. The principle difference between migration and invasion is that migration refers to normal cell movement; whereas invasion describes cells actively invading surrounding tissue. It can do this under the influence of a chemoattractant gradient and secretion of proteases. There are numerous methods for performing these assays including scratch assays performed on a monolayer of cells adhered to plasticware (microplates or culture inserts) or using 3D cell culture models.
- Developmental Biology
  A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. An approach following this viewpoint is the use of whole organism models involving living invertebrates and vertebrates such as nematodes and zebrafish conducive to drug screening methods.
- Histology and Slide Scanning
  Histology is typically performed on fixed tissue samples using upright microscopes equipped with oculars. Cytation™ and Lionheart™ FX provide automated digital imaging of these samples using color brightfield microscopy. Low to high magnifications from 1.25x to 60x (100x with Lionheart FX) can be combined with Cytation Gen5™ image processing features such as image stitching to increase field of view.
- Immunology
  The immune system relies on diverse mechanisms working in concert to defend the host from infection and to identify and remove aberrant or damaged cells. Dysregulation of the immune system can lead to a variety of disease conditions, including autoimmune disorders, allergies, and cancer. Additionally, the immune system is a critical consideration for vaccine development and cell, tissue and organ transplants.
- Immuno-Oncology
  While harnessing the patient’s immune system to fight cancer is not a new concept, there have been significant strides in the past decade to more effectively direct and activate components of the immune system and counter the measures certain tumors adopt to shield itself from immune attack. These include immunotherapeutic drugs based on directing immune cells to tumors based on specific antigens they present, PD-1 checkpoint inhibition and the ex vivo manipulation of the patient’s own immune cells to better drive an immune response to cancer.
- Microbiology
  Since the advent of a lens system that enabled the visualization of bacteria and protists in 1671, the microscope remains a ubiquitous tool for the scientific study of live and fixed microorganisms. Investigating the structure, function, and typing of the highly diverse array of microorganisms spans heterogeneous applications including, but not limited to, the elucidation, diagnosis, and treatment of human and plant disease, food and water safety testing, vaccine development, investigation and production of industrial lipases, protein transfection to mammalian cells, environmental health and impact appraisal, horticultural and agricultural soil assessment, and exploration of alternative fuel sources.
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  Biochemical assays run the gamut from routine ELISAs to micro-volume nucleic acid and protein quantification. Endpoint and kinetic, single- and multi-wavelength assays are essential experimental tools. BioTek’s multi-mode readers have the flexibility to accommodate a very broad range of applications with superior performance.
- Rapid Cell Signaling
  G-protein coupled, seven-transmembrane (7-TM) receptors (GPCRs) represent large, diverse gene families found in fungi, plants and animals. The GPCR family of receptors is involved primarily with internalizing extracellular environmental signals via interaction with intracellular G-proteins. GPCR ligands and modulators range from peptide and non-peptide molecules to chemokines, nucleosides, growth factors and light.
- Stem Cell Research
  Research into the reprogramming of somatic cells into pluripotent stem cells received the Nobel Prize in 2012. The long term importance of this research resides in the use of stem cells for regenerative therapies; for the short term, however these cells represent a potential unlimited source of highly physiologically relevant cells, akin to human primary cells, that can be used as drug discovery reagents.
- Virology
  Research into the diverse aspects of virology are made possible by a broad range of applications and assay formats, from relatively simple methods for viral detection to those designed to elucidate complex immune responses and pathological processes. BioTek instruments provide versatile platforms for conducting viral research, with optimized imaging- and plate reader-based solutions, as well as liquid handling and automation tools for increased assay throughput and reproducibility.
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  Synergy H1’s Continuously Variable Bandwidth Monochromators Optimize Assay Performance
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  LogPhase 600 Microbiology Reader Measures Microbial Growth Curves in Multiple Microplates
  June 9, 2020 - BioTek unveils a unique class of microplate readers with the new LogPhase 600 Microbiology Reader. The LogPhase 600 is the only four-plate microplate reader purpose-built to perform microbial growth curve analysis. Multiple plate measurements increase throughput and reduce the need for multiple costly single-plate absorbance readers that take up valuable bench space. At the same time, highly consistent environmental conditions support high quality absorbance results without growth curve artifacts, even in bacterial and yeast assays with extended incubation periods. Read more
  
  Agilent’s BenchCel Microplate Handler Now Available through BioTek for Full Workflow Automation
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Home SARS-CoV-2 Research General Virology Applications

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product design

Viral Growth/Titration

Viral titration assays allow quantification of virus concentration and production and isolation of purified virus. BioTek Imaging and Microscopy instruments with Gen5™ Image Analysis Software automate viral growth and titration assays.

Detection of CPE
Calculation of TCID₅₀
Fluorescent FFA
Plaque assay

Viral Replication Kinetics

Viral replication and growth kinetics provide key information for understanding virus-host interactions. BioTek Imaging and Microscopy instruments and Automation accessories provide live cell imaging and analysis capabilities.

Viral growth kinetics
Subcellular localization during virus lifecycle
Replication complexes

Viral Detection

For both basic research and clinical applications, the ability to quickly detect virus in a sample is key to any virology pipeline. With BioTek Imaging and Detection instruments, virus can be detected using a variety of methods, while BioTek Liquid Handlers and Stackers increase assay efficiency and throughput.

Rapid ELISA screen
Fluorescent detection of immunolabed/reporter strains
Screening antibodies for viral detection

Learn more about Virology applications

Accelerate your Research

Cytation™ 7 Cell Imaging Multi-Mode Reader

Fast widefield imaging system for viral plaque assays

Multi-mode plate reader with sophisticated imaging
Comprehensive Imaging Solution
Hit-picking: Multi-mode detection + imaging saves time and data storage
ELISpot Imaging
Powerful functionality with ROI identification feature
Variable bandwidth for sensitivity and specificity
Micro-volume analysis with Take3 plate

EL406™ Washer Dispenser

Automate viral antigen and antibody ELISA with EL406 and Stacker

Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument
96-, 384- and 1536-well plate compatible
Gentle processing for cell-based assays
Bead washing: magnetic and polystyrene
Easy maintenance with Ultrasonic Advantage™
Automatically process up to 50 plates with BioStack™

Ask a Specialist