Cell Stress

Endoplasmic reticulum (ER) mediated cell stress and the unfolded protein response (UPR) serve as a major stress pathway in eukaryotic cells. ER stress and the UPR can be triggered by a number of cellular perturbations including misregulation of ER Ca2+, accumulation of misfolded proteins within the lumen of the ER, and reactive oxygen species. Activation of proteostatic pathways, such as the UPR and ER-stress serves as an early indicator of treatment-induced cell stress or toxicity. Combining automated live cell imaging and analysis with the reversible cell stress biosensor from Montana Molecular provides a sensitive and reversible method for detecting the UPR and ER-stress in real time.

 

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Learn more about Cell Stess applications - search our Application Notes and technical documentation in Resources.

 

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