BioTek: Microplate Instrumentation & Software Solutions
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Liquid Handling Control™ Software

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Liquid Handling Control (LHC) Software interfaces with BioTek washers and dispensers

Liquid Handling Control™ (LHC™) Software is a powerful yet flexible interface for use with BioTek's 405™ Touch Washer, 405™ LS WasherELx405™ Select Deep Well WasherEL406™ Washer Dispenser,  and MultiFlo™ Dispenser.  Full PC control provided by LHC Software leads to increased convenience when programming important assay-specific protocol requirements in a familiar Windows® environment. Any programming sequence possible onboard the washer or dispenser may be duplicated from the computer with LHC. With intuitive StepWise™ protocol creation, even novice users will find LHC Software easy to use.

21 CFR Part 11 compliance

To meet the demands of the GxP laboratory, LHC™ Secure offers features to ensure compliance to the U.S. FDA's 21 CFR Part 11 directive.  Flexible multi-user permission levels and electronic protocol and system audit trail signing are all available whenever additional security is required. 

Expanded versatility, Automatic protocol validation 

LHC Software allows an unlimited number of methods to be linked together for the most complex liquid handling routines. From an instrument’s first prime routine, multiple microplate processes over time, an ultrasonic cleaning to dissolve protein or salt crystal build-up to a final system rinse, LHC Software enables unattended operation.  Protocols are automatically validated to ensure feasibility and compatibility with the selected instrument. 

Dual mode control

Dispense protocols can be created and run from the PC or downloaded to the instrument’s keypad.  This is particularly useful when the liquid handler is installed in a biological safety cabinet.  Protocols can be locked to avoid unintentional keypad modifications. 

Custom maintenance reminders

To facilitate maintenance and keep a washer or dispenser in peak condition, factory recommended maintenance procedure reminders can be preset and customized appropriate for a busy laboratory’s usage and throughput requirements. 

Safe record keeping

Protocol parameters may be printed for safe record keeping.  Alternatively, onboard instrument protocols are able to be uploaded and backed up on a laboratory’s network.  Satellite research labs working on joint projects can be certain their wash parameters are identical for experimental integrity. 


For batch processing applications, LHC Software supports BioStack™ Microplate Stacker integrations. Robotic integration of BioTek washers or dispensers to commercially available robotic systems is also seamless with Liquid Handling Control. Minimum System Requirements:

  • Microsoft® Windows®7, Windows®Vista™, Windows®XP – Professional Editions, 32- and 64-bit versions
  • Intel® Pentium IV-Class or AMD compatible processor (1.33 GHz or higher)
  • 512 MB RAM or higher
  • 2 GB hard drive space or higher
  • Designed for XGA resolution at 1024 x 768 or higher
  • CD-ROM readable drive
  • Keyboard and mouse
  • Microsoft® Internet Explorer®v5.0 or higher (for online Help)
  • Serial or USB port(s) for one or more BioTek instruments
  • Full control of BioTek liquid handlers such as 405 Touch, 405 LSELx405 Select Deep WellEL406, and MultiFlo
  • Program assay-specific requirements in familiar Windows® environment
  • Intuitive StepWise™ protocol creation with an unlimited number of methods included for ultimate flexibility
  • Automatic protocol validation for error-free assurance
  • Dual mode control – create and run protocols from PC or download to instrument’s keypad
  • Security enabled protection for downloaded protocols
  • Printed protocol reports
  • Custom maintenance reminders for continued instrument performance in busy laboratories
  • Multiple instruments controlled in parallel, including BioStack integrations for unattended batch processing
  • LHC Secure additionally offers:
    • Full compliance with the United States Food and Drug Administration’s 21 CFR Part 11 regulation
      • User permission levels and authentication
      • Time stamped protocol and system audit trails
      • Embedded signatures
    • Automatic protocol history
    • Email alerts


Intuitive StepWise™ protocol creation for ultimate flexibility.

Compliance to the FDA's 21 CFR Part 11 directive with multi-user permission levels.

Individual methods can be written and then imported into other protocols for maximum programming efficiency.

Factory recommended maintenance reminders can be customized for continued instrument performance in busy laboratories.

Liquid Handling Control PC Software - Includes LHC Software on CD, Installation Guide and 5 licenses. For use together with 405 Touch Washer, 405 LS Washer, ELx405 Select Deep Well Washer, EL406 Washer Dispenser and MultiFlo Dispenser.

LHC Secure Software provides features to facilitate compliance to FDA directive 21 CFR Part 11 or whenever additional security is required. For PC control of 405 Touch Washer, 405 LS Washer, ELx405 Select Deep Well Washer, EL406 Washer Dispenser and MultiFlo Dispenser. Includes software on CD, Installation Guide and 5 licenses.

Standard (Included)

Operators Manual

MANUAL Operator's manuals can be obtained via the Customer Resource Center

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