EL406 Washer Dispenser

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Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument

Combines fast microplate washing with 3 reagent dispensers in 1 compact instrument

96-, 384- and 1536-well plates

96-, 384- and 1536-well plates

Full automation of intra-assay liquid handling steps

Full automation of intra-assay liquid handling steps

The EL406 Combination Washer Dispenser offers fast, full plate washing along with three reagent dispensers in one, compact instrument… all from the recognized industry leader. The EL406 is the latest advancement in 1536-, 384- and 96-well microplate washing and dispensing incorporating BioTek’s patented Dual-Action™ manifold, optimized washing for loosely adherent cell monolayers, built-in patented Ultrasonic Advantage™ for unattended wash manifold maintenance and up to four wash buffers for complex wash routines.

BioTek’s EL406 magnetic bead washing module offers high strength biomagnetic separation in both 384- and 96-well microplates. Based upon what is regarded as the industry standard in microplate washing, BioTek’s EL406™ Microplate Washer Dispenser offers full plate washing of magnetic microspheres used in a growing number of multiplex assays and bead-based ELISAs along with reagent dispensing. Developed in conjunction with leaders in genotyping, gene expression and protein assays built upon the Luminex® xMAP® platform, BioTek’s magnets incorporate high-energy neodymium iron boron magnets for rapid separation of micrometer and nanometer beads with superior retention. An accessory magnet adapter kit allows any EL406 configuration to accommodate magnetic bead assay washing and dispensing. An available vacuum filtration module makes the EL406 also well suited for polystyrene bead assays and filtration-to-waste processes. The EL406 Washer Dispenser is Luminex® xMAP® approved.

Up until now scientists had to choose their microplate dispenser technology - usually between either a peristaltic or syringe pump. Each of these technologies has its unique advantages. The EL406 eliminates the need to choose, offering both dispenser technologies on a single platform plus microplate washing. Now you can simply press a button and walk away. Automate an entire process by adding a BioStack™ Microplate Stacker.

The EL406 can be used for applications such as:

  • ELISA Automation
  • MSD Automation
  • High Content Screening Immunocytochemistry
  • Label-free Cell-based Assays – especially 1536-well density
  • FLIPR® Ca2+ flux
  • Magnetic and Polystyrene Bead Assay Automation for gene- and protein-expression

US Federal Government customers: This product is available on GSA contract. Contact BioTek Customer Care with questions or submit a Quote Request Form to receive pricing and information on specific models (please note GSA Contract in the Comments field).

xMAP® is a registered trademark of Luminex® Corporation.
FLIPR® is a registered trademark of Molecular Devices®

  • 1536-, 384- and 96-well microplates
  • Magnetic and polystyrene microsphere assays
  • ELISAs and cell-based assays
  • High-energy neodymium iron boron magnets
  • Selection of optimized field gradients within wells
  • Rapid separation of micrometer and nanometer beads with superior retention
  • Fast and efficient vacuum filtration
  • Fast microplate washing and dispensing
  • Patented Dual-Action™ wash manifold
  • Unique Parallel Dispense capability: Dispense multiple reagents without carryover.
  • Unattended operation for long and tedious liquid handling processes
  • Smaller benchtop or robotic system footprint compared to separate washer and three dispensers
  • Compatible with BioSpa™ 8 Automated Incubator for multi-functional workflow automation
  • BioStack™ compatible for automated processing of up to 50 standard height microplates
  • Choice of software control from instrument keypad or Liquid Handling Control™ (LHC) PC software
  • Built-in ultrasonic cleaner
  • Automatic switching of up to four wash buffers or reagents

 

Part # 1536-/ 384-/ 96-well 1536-/ 384-well 1536-well 384-/ 96-well 384-well 96-well 3 reagent disp. 2 reagent disp. 1 reagent disp.
406PSUB3SB              
406PSUB3LB              
406PSUB1SB              
406PSUB1LB              
406PSUB2SB              
406PSUB2LB              
406PSU0SB              
406PSU0LB              
406SNA0LB              
406PSUB3              
406PSUB1              
406PUB3              
406PUB1              
406PSUB2              
406PUB2              
406PSNA4              
406SNA4              
406P4              

 

EL406™ 1536-/384-/96-well Microplate Washer Dispenser Configurations
  Feature Design
P 1-Reagent Dispense Module –
1 Peristaltic Pump
  • Autoclavable
  • 8-tip (1 x 8) cassette
  • Sapphire jeweled, steel or plastic tips
S 2-Reagent Dispense Module –
2 Syringe Pumps
  • Autoclavable
  • 2 16-tube (1 x 16) manifolds
  • Steel tubes
SNA 2-Reagent Dispense Module –
2 Syringe Pumps
  • Non-autoclavable
  • 1 16-tube (2 x 8) manifolds - except with P/N 406SNA0-LB
  • Steel tubes
U Wash Module – Ultrasonic Advantage™  
B Wash Module – Automatic 4-Buffer Switching  
1 Wash Module – 384-/96-well microplate washing
2 Wash Module – faster 384-well microplate washing
  • Dual-Action™
  • 192-tube (16 x 12) manifold
  • Steel tubes
3 Wash Module – 384-/96-well microplate washing
  • Dual-Action™
  • Interchangeable 96-tube (384-/96- well washing) and 192-tube (faster 384-well washing) manifolds
  • Steel tubes
4 Wash Module – 96-well microplate washing
  • 96-tube (8 x 12) manifold
  • Steel tubes
SB Wash Module – 1536-well microplate washing and dispensing
  • 2 32-tube (1 x 32) dispense manifolds
  • Small bore, sapphire jeweled tubes
  • 128-tube (4 x 32) aspiration manifold
LB Wash Module – 1536-well microplate washing and dispensing
  • 2 32-tube (1 x 32) dispense manifolds
  • Large bore, steel tubes
  • 128-tube (4 x 32) aspiration manifold

 

General
Microplate Types 96-, 384- and 1536-well
Low profile and standard height
Solid and filter bottom (option)
Onboard Software Create, edit or run multiple protocols
Software (pc control) LHC2 Software
LHC2 Secure for 21 CFR Part 11 compliance (option)
SiLA Compliant driver (option)
Separation Biomagnetic separation, vacuum filtration (optional)
Shaking Programmable up to 60 minutes
Slow, medium, fast or variable
Soaking Programmable up to 60 minutes
Ultrasonic Advantage™ Standard on most configurations
Automation BioStack and 3rd party automation compatible
BioSpa 8 Automated Incubator compatible
Washing
Manifold Types 96-well washing: 96-tube manifold - straight dispense tubes
96- and 384-well washing: 96-tube Dual-Action manifold - 20° angled dispense tubes
384-well washing (fast): 192-tube Dual-Action manifold - 7° angled dispense tubes
1536-well washing: Two 32-tube dispense manifolds - 7° angled dispense tubes
Volume Range 3 - 3,000 µL/well in 1 µL increments
Wash Cycles 1 - 250
Buffer/reagent selection Auto switching module for up to 4 buffers (option)
Supply Bottle 4 L or 10 L (optional)
Dispense Accuracy +3%
Dispense Precision <3% CV (model dependent)
Residual Volume <2 µL/well
Wash Speed 96 wells, 300 µL/well, 96-tube manifold: 13 seconds
384 wells, 100 µL/well, 192-tube manifold: 17 seconds
1536 wells, 10 µL/wells, two 32-tube manifolds: 36 seconds
Flow Rates High flow to low flow
Optimized rates for cell assays
Sterilization Chemical
Vacuum range for filtration Selectable: 0 to -380 mmHg (final at 30s)
Filtration time: 5 - 999 seconds
Dispensing - Peristaltic pump (Multi-Channel)
Manifold Types 8-tip (1 x 8) cassette with plastic, 316 SS tubes or sapphire jeweled 316 SS tubes
Fluid Delivery 1 or 2 peristaltic pumps
Dispense Speed 96 wells, 10 µL /well: 8 seconds
384 wells, 5 µL /well: 12 seconds
1536 wells, 1 µL /well: 27 seconds
Volume Range 500 nL - 3,000 µL/well, selectable in 1 µL increments
Flow Rates User programmable rates from high to low
Optimized rates for cell assays
Dispense Performance 1 µL cassette:
Recommended Volume Range: 1 - 50 µL
Dispense Accuracy: +5% at 1 µL
Dispense Precision: <5% CV at 1 µL
<10% CV at 500 nL
Minimum Prime Volume: 1.20 mL
5 µL cassette:
Recommended Volume Range: 5 - 2,500 µL
Dispense Accuracy: +2.0% at 5 µL
Dispense Precision: <2.5% CV at 5 µL
Minimum Prime Volume: 4.23 mL
10 µL cassette:
Recommended Volume Range: 10 - 3,000 µL
Dispense Accuracy: +2.0% at 10 µL
Dispense Precision: <2.0% CV at 10 µL
Minimum Prime Volume: 7.36 mL
Recommended cassette replacement interval 1 µL Cassette: 1,000 384-well microplates at 5 µL well
5 µL Cassette: 1,000 96-well microplates at 50 µL well
10 µL Cassette: 1,000 96-well microplates at 100 µL well
Sterilization Autoclave, chemical
Dispensing - Syringe pump
Manifold Types 96-well dispensing:
One 16-tube (2 x 8) manifold - 316 SS tubes
96-/384-well dispensing:
Two 16-tube (1 x 16) manifolds - 316 SS tubes
1536-well dispensing:
Two 32-tube (1 x 32) manifolds - sapphire jeweled 316 SS or 316 stainless steel tubes
Fluid Delivery Two positive displacement syringe drives
Dispense Speed 20 µL /well, 96 wells, 1 x 16 tubes: 5.25 seconds
20 µL /well, 384 wells, 1 x 16 tubes: 14 seconds
3 µL /well 1536 wells, 2 x 32 tubes: 7 seconds
Volume Range 3 - 3,000 µL/well, selectable in 1 µL increments
Minimum Prime Volume: 12 mL
Flow Rates User programmable rates from high to low
Dispense Accuracy +1 µL at 5 µL
+1 µL at 20 µL
+1% at 100 µL
Dispense Precision <5% CV at 5 µL
<2.5% CV at 20 µL
<1% CV at 100 µL
Supply Bottle 1 L or 2 L
Sterilization Chemical, autoclavable option
Physical Characteristics
Power 100 - 240 Volts AC. 50/60 Hz
Dimensions 16.5" W x 18" D x 12.5" H (42 x 46 x 32 cm)
Weight 32 lbs (14.5 kg)
Regulatory
Regulatory CE and TUV marked. ROHS compliant. In Vitro Diagnostic use models are available.

Specifications are subject to change. Performance values represent the average observed factory test values.

Optional

BioSpa 8 Automated Incubator

BioSpa 8 Automated Incubator

BioSpa 8 is an automated incubator linking BioTek readers or imagers together with washers and dispensers for full workflow automation of up to 8 microplates. Temperature, CO2/O2 and humidity levels are controlled and monitored through the BioSpa software to maintain an ideal environment for cell cultures during all experimental stages.


BioStack Microplate Stacker

BioStack Microplate Stacker

BioStack™ is a compact and versatile microplate stacker compatible with BioTek’s washers, dispensers, detectors and imaging systems. BioStack offers rapid plate exchange speeds to increase throughput and enhance productivity, accommodating assay workflows both with and without plate lids.


Liquid Handling Control™ Software

Liquid Handling Control™ Software

Software is a powerful yet flexible interface for use with BioTek’s liquid handlers including the 405™ Microplate Washer, the ELx405™ Select Deep Well Washer, the EL406™ Washer Dispenser and the MultiFlo™ Dispenser. New LHC Secure offers compliance to the FDA directive 21 CFR Part 11 or whenever additional security is required.


Standard (Included)

Operators Manual

MANUAL Operator's manuals can be obtained via the Customer Resource Center

Optional

BioStack Integration Kits

7310042 BioStack Integration Kit for EL406 accessory has picture

Bottles & Tubing

7100531 Cap for Waste Bottle, 4L (Also fits 10L or 20L) accessory has picture
7100532 Spare Cap for 4L Dispense Bottle accessory has picture
7100534 Waste Bottle, 4L accessory has picture
7100543S Waste Set with Level Sensing, 4L Bottles accessory has picture
7100544 Cap for Waste Bottle with Level Sensing, 4L accessory has picture
7100556 Waste Bottle and Tubing, 20L accessory has picture
7100557 Waste Bottle and Tubing, 10L accessory has picture
7100559 Dispense Bottle (10L) accessory has picture
7180541 Dispense Tubing Set - Teflon Lined
7183002 Supply Tubing Set for DMSO & Acetonitrile for 2 Syringe Pump Dispensers
7183006 Spare Tubing Set for 2 Syringe Pump Dispensers

Cassettes

7170007 Large Volume Replacement Tubing Set (10 µL) - molded plastic tips accessory has picture
7170008 Medium Volume Replacement Tubing Set (5 µL) - molded plastic tips accessory has picture
7170009 Low Volume Replacement Tubing Set (1 µL) - molded plastic tips accessory has picture
7170010 Large Volume (10 µL) Cassette - molded plastic tips accessory has picture
7170011 Medium Volume (5 µL) Cassette - molded plastic tips accessory has picture
7170012 500 nL – 50 µL, 1 µL increments, cassette, plastic tips accessory has picture
7170013 Large Volume (10 µL) Cassette - stainless steel tips accessory has picture
7170014 Medium Volume (5 µL) Cassette - stainless steel tips accessory has picture
7170015 500 nL – 50 µL, 1 µL increments, cassette, sapphire jeweled stainless steel tips accessory has picture
7170016 500 nL - 50 µL, 1 µL increments, 1536-well cassette, steel tips accessory has picture
7170018 500 nL - 50 µL, 1 µL increments, 1536-well cassette, plastic tips accessory has picture
7170020 Large volume (10 µL) Cassette Tubing Extension Kit accessory has picture
7170021 Medium volume (5 µL) Cassette Tubing Extension Kit accessory has picture
7170022 Low volume (1 µL) Cassette Tubing Extension Kit accessory has picture
7170023 Large Volume (10 µL) Cassette - large bore, molded plastic tips
7170024 Medium Volume (5 µL) Cassette - large bore, molded plastic tips
7170025 Large volume replacement tubing set (10 µL) – molded plastic large bore tips
7170026 Medium volume replacement tubing set (5 µL) – molded plastic large bore tips

Dispense/Waste Systems

1170560 Complete Direct Drain Waste System 115V/230V, 4L Bottles
1170561 Direct Drain Waste System Upgrade Kit 115V/230V, 4L Bottles
1170562 Complete Direct Drain High Flow Waste System 115V/230V, 4L Bottles
7100581S Dispense System Complete Assembly, 10L accessory has picture
7100582S Vacuum Set with Level Sense Assembly, 10L accessory has picture
7100745S Complete Dispense/Waste System 115/230V, 4L Bottles accessory has picture
7100746S Complete Waste System 115V/230V, 4L Bottles accessory has picture
7100751 Complete Dispense/High Flow Waste System 115V/230V, 4L Bottles accessory has picture
7100752 Complete Dispense/High Flow Waste System 115/230V, 10L Bottles accessory has picture
7100753S Complete High Flow Waste System 115V/230V, 4L Bottles
7100754 High Flow Vacuum Pump 115/230V
7100763 Complete Dispense/High Flow Waste System 115V/230V, 10L bottles
7103034 Standard Vacuum Pump 115V/230V accessory has picture

Filters

49943 Dispense Fluid Inlet Screen
48294 Filter for Waste Tubing accessory has picture

Manifolds

7180549S 8-tube (1x8) Large bore manifold for 96-well Microplates autoclavable

Miscellaneous

4030551 Vacuum Gauge/Regulator
7100025S Stylus Kit for any 405™/ELx405™ Select Deep Well manifold accessory has picture
7100096 15' extension kit for use with robotic system integrations of Elx405 Select Deep Well, EL406
7102215 384-well Ring Magnet accessory has picture
7102216 96-well Ring Magnet accessory has picture
7103016 96-well Flat Magnet accessory has picture
7103017 384-well Flat Magnet accessory has picture
7180006S 2 Syringe Pump Dispenser Module - Autoclavable Upgrade Kit
7180010 Peristaltic Pump Angled Dispense Kit accessory has picture
7180011 Magnet Adapter Kit
7180028 EL406 Dual Syringe Dispenser Automatic Reagent Switching Module accessory has picture
7180029 EL406 Vacuum Filtration Module Accessory accessory has picture
7182109 40 mL Capacity Dispenser Priming Trough accessory has picture
7210509 Spare Reservoir Holder and Strap
7210515 3-Instrument Rack – for third party robotic system integration accessory has picture

Product Qualification Packages

7180527 EL406 Qualification Package

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